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Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M: Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial.
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In a study of elderly patients with diabetes type 2, "After 12 months of therapy, there was a statistically significant difference in the change in glycated haemoglobin (HbA(1c)) (-0.
The mechanism of weight loss is related to increased satiety and the delay in gastric emptying resulting from the exogenous administration of GLP-1; therefore, GLP-1 therapy might not be appropriate in patients with severe GI disease (i.
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An electronic search without language restrictions was performed in Medline (using PubMed), EMBASE and the Cochrane Library (April 17 2013).
All that C-peptide test shows is that you are making insulin.
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Effect of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors on colorectal cancer incidence and its precursors.
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Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using DPP-4 inhibitor: the Sitagliptin Preventive study of Intima-media thickness Evaluation (SPIKE).
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Biguanides: Metformin falls into this category; some brand names include Diaformin, Diabex and Glucomet.
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Department of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, Belgium.
SIDE EFFECTS: Diarrhea, gas, upset stomach, constipation, or stomach pain may occur in the first few weeks of treatment as your body adjusts to this medication but usually improve with time.
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If patients declined to return for study visits, information was obtained during telephone contacts, but this was not the preferred approach nor was it recommended to the sites.
The first occurrence of each type of event was analysed.
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Stress-induced cellular and molecular changes, uniquely at the true of gene transcrip- tion, are being elucidated through in vitro studies and afterwards the biological effects of these changes are being well-thought-out in animal models.
Alogliptin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus.
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Yet shortcomings of this particular study were that CV disease was not looked at prospectively and, in fact, CV disease or events were not assessed at all, but rather a complex CV risk factor score was used instead.
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Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
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Do we need new indicators of dialysis adequacy based on middle-molecule removal?
Complementary therapy in diabetic patients with chronic complications: a pilot study.
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In addition to the adult muscular form, CPT I or CPT II deficiency may cause a rare but severe and fatal disease in the neonatal period and during early infancy.
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When taken too low, deviations from the target blood sugar level are not corrected for effectively, when taken too high, the blood sugar regulation will become unstable.
Long-term management strategies are therefore required that are effective at controlling dysglycaemia, well tolerated and, ideally, offer additional cardiovascular disease (CVD) risk-reduction benefits.
What are the performance characteristics of diagnostic tests for type 2 diabetes in women with gestational diabetes?
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Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.
Falko Brettschneider, Markus Tölle, Markus von der Giet, Jutta Passlick-Deetjen, Sonja Steppan, Mirjam Peter, Vera Jankowski, Alfred Krause, Sophie Kühne, Walter Zidek, Joachim Jankowski.
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Within-laboratory imprecision also varied, with some methods giving much more consistent results than others.
Risk of overall mortality and cardiovascular events in patients with type 2 diabetes on dual drug therapy including metformin: A large database study from the Cleveland Clinic.
After the age-related entry criteria and race had been accounted for, mortality in our study was similar to that in the general population of patients in the United States undergoing hemodialysis.
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At 6 years, patients allocated to insulin had lower fasting plasma glucose levels than did patients allocated to oral agents, but hemoglobin A 1c concentrations were similar.
The purpose of this study was to determine the impact of using grapefruit juice while maintaining a diet that was high in fat which is typical of many Americans.
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Findings demonstrate that consistent exercise training, even without accompanying improvements in body composition, improve peripheral insulin activity in subjects with impaired glucose tolerance.
After having too many side effects with Metformin and severe reaction with Pioglitazone, I was prescribed Acarbose ( all generic names).
These data confirmed that acarbose had similar efficacy to other anti-diabetic drugs, including vildagliptin, nateglinide, and metformin, in terms of reducing HbA 1c and fasting and postprandial glucose levels.
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Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A).
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The study included a higher percentage of blacks (63 percent) than this overall population does, because of the predominance of urban centers, but patients with diabetes, elderly patients, and patients with cardiac disease were well represented.
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Rhabdomyolysis results in marked elevation of serum CK and the release of myoglobin into the plasma.
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If C-peptide has some useful function, then is it missed?
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Outpatient visits were scheduled at the time of screening, at randomization, and at 1, 3, 6, 9, and 12 months after randomization during the first year of the study and every 4 months during subsequent years of participation.
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